DSIP Rx

Sources

DSIP References: Every Study Cited Here

The complete list of peer-reviewed sources behind the claims on this site, with DOIs and PubMed links.

About these references

Every quantitative claim across this DSIP digest is tied to a numbered source below, drawn from the peer-reviewed literature — PubMed-indexed journals including PNAS, the Journal of Neurochemistry, Peptides, and others. The list runs from the 1977 isolation paper to a 2024 study of an engineered DSIP fusion peptide. Where a study is paywalled, the DOI and PubMed link still let you locate the abstract and citation. The full reference details are listed in the sources section that follows.

  1. Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci U S A. 1977;74(3):1282-1286. ↗
  2. Schneider-Helmert D, et al. The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep. Experientia. 1981;37(8):913-914. ↗
  3. Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006;97(2):303-309. ↗
  4. Bjartell A, Ekman R, Bergquist S, Widerlov E. Reduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in man. Psychoneuroendocrinology. 1989;14(5):347-355. ↗
  5. Popovich IG, Voitenkov BO, Anisimov VN, et al. Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. Mech Ageing Dev. 2003;124(6):721-731. ↗
  6. Mu X, Qu L, Yin L, Wang L, Liu X, Liu D. Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models. Front Pharmacol. 2024;15:1439536. ↗
  7. Sudakov KV, et al. The effects of delta sleep-inducing peptide on incidence and severity in metaphit-induced epilepsy in rats. Pharmacol Res. 2002;45(3):237-243. ↗
  8. Khvatova EM, et al. Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia. Peptides. 2003;24(2):307-311. ↗
  9. Khvatova EM, et al. Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke. Molecules. 2021;26(17):5173. ↗
  10. Bjorkman ST, et al. DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion. Biomedicines. 2021;9(4):407. ↗
  11. Khvatova EM, Rubanova NA, Prudchenko IA, Mikhaleva II. Effects of delta-sleep inducing peptide (DSIP) and some analogues on the activity of monoamine oxidase type A in rat brain under hypoxia stress. FEBS Lett. 1995;368:367-369. ↗
  12. Tsunashima K, Masui A, Kato N. The effect of delta sleep-inducing peptide (DSIP) and phosphorylated DSIP (P-DSIP) on the apomorphine-induced hypothermia in rats. Brain Res. 1990;510:171-174. ↗
  13. Bjartell A, Castro MG, Ekman R, Sundler F, Widerlöv E, Loh YP. Immunoreactive delta sleep-inducing peptide secretion from mouse dissociated, anterior pituitary cells: regulation by corticotropin-releasing factor and arginine vasopressin. Neuroendocrinology. 1989;50:564-569. ↗
  14. Bjartell A, Ekman R, Hedenbro J, Sjölund K, Sundler F. Delta sleep-inducing peptide (DSIP)-like immunoreactivity in gut: coexistence with known peptide hormones. Peptides. 1989;10:163-170. ↗
  15. Ahlman H, Ahlund L, Nilsson O, Dahlström A, Bjartell A, Ekman R. Coexistence of delta sleep-inducing peptide and serotonin in midgut carcinoid tumour cells in vivo and in vitro. Int J Cancer. 1989;44:641-647. ↗